ea0094p210 | Metabolism, Obesity and Diabetes | SFEBES2023
Cassidy Ben
, Firkins Louise
, Sagmeister Michael
, Crastin Ana
, Poologasundarampillai Gowsihan
, Harper Lorraine
, W. Jones Simon
, S. Hardy Rowan
Background: Skeletal muscle wasting is a characteristic feature of chronic kidney disease (CKD), associated with increased hospitalisations and premature mortality. Excess glucocorticoid signalling is a major contributor to the pathogenesis of muscle wasting in conditions of renal impairment. This study aimed to validate a murine model of CKD and utilise this to determine if deletion of 11beta-hydroxysteroid dehydrogenase type 1 (11β-HSD1) provides protec...